Oxidation induced by the antioxidant glutathione (GSH)
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چکیده
منابع مشابه
Oxidation induced by the antioxidant glutathione (GSH).
Remarkably efficient oxygen atom transfer from an intermediate of glutathione (GSH) autoxidation to an organometallic ruthenium arene thiolato complex is observed under physiologically-relevant conditions.
متن کاملGlutathione, Reduced (GSH) Monograph
Introduction Reduced glutathione, most commonly called glutathione or GSH, is a relatively small molecule ubiquitous in living systems. Occurring naturally in all human cells, GSH is a water-phase orthomolecule. Its intracellular depletion ultimately results in cell death and its clinical relevance has been researched for decades. GSH is the smallest intracellular thiol (–SH) molecule. Its high...
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Current studies provide evidence that proteins are initial targets of ROS (reactive oxygen species) in biological systems and that the damaged proteins can in turn damage other cell constituents. This study was designed to test the possibility that protein radicals generated by ROS can oxidize GSH and assess the probability of this reaction in vivo by measurement of the rate constant of this re...
متن کاملThe Oxidation of Glutathione by Serum.
Studies of serum glutathione reductase activity in thislaboratory prompted an attempt to demonstrate glutathione oxidase in the serum. The oxidation of reduced glutathione in the sera of patients with various diseases does not differ from normal sera. Preheating the serum and addition of cytochrome c does not effect the oxidizing capacity of the serum. The ability of serum to oxidize reduced gl...
متن کاملChanges in GSH-antioxidant system induced by daunorubicin in human normal and diabetic fibroblasts.
We investigated the effect of daunorubicin on glutathione content and activity of GSH-related enzymes in cultured normal and diabetic human fibroblasts. Cells were incubated with 4 microM daunorubicin (DNR) for 2 h followed by culture in drug-free medium for up to 72 h. Treatment of diabetic cells with the drug caused a time-dependent depletion of intracellular GSH and a decrease of the GSH to ...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2008
ISSN: 1359-7345,1364-548X
DOI: 10.1039/b805358h